The Harrogate Bus Company said the "town centre is completely blocked" as emergency services bring the fire under control.
The bus station is closed - some services have been cancelled, and others are running on altered routes and diversions from different bus stops.
What we know about the fire so far
A large fire has broken out at a shop unit in Harrogate town centre.
Where is the fire?
More than five fire engines are on the scene at the blaze, which is on Station Parade and backs onto Beulah Street.
Which shop is it?
It's believed to be at Deli Blanca - the former Tommy Gun's shop unit
Station Parade is closed while fire crews work to bring the blaze under control, and Cheltenham Parade is also closed off.
Advice from emergency services
North Yorkshire Fire and Rescue Service has advised people to avoid the area.
How bad is the fire?