Harrogate Town exited the FA Cup at their first hurdle after losing 1-0 at Skrill North rivals Colwyn Bay.
Cameron Darkwah’s six yard effort in the closing stages ensured Town would have no repeat of last year’s unbelievable cup run.
Ashley Worsfold had earlier been denied by a goalline clearance and Town also hit the crossbar.
But for the fourth game in a row, Simon Weaver’s side lost out by a single goal.
Town will be back on the road next Saturday when they travel to Gainsborough Trinity.
Harrogate Railway completed the loan signing of young Leeds United goalkeeper Eric Grimes before Mossley’s visit to Station View.
Grimes came straight in to the starting 11 for the clash as dual registered stopper Peter Crook travelled with Town to sit on the bench at Colwyn Bay.
But the ‘keeper’s Railway debut ended in despair as his side lost 1-0 despite a brave, battling display at Station View.
Billy Miller’s men played more than 85 minutes with 10 men after Mike Morris was sent-off.
Mossley scored from the resultant free-kick, before adding a second from another free-kick on 22 minutes.
Railway improved in the second period, but failed to get themselves back into the game.
Harrogate RUFC suffered a fourth defeat on the bounce in their return to National League Two North, falling down 34-17 to Darlington Mowden Park at Claro Road.
The scores were tied at 10-10 at the break but again ill-discipline cost Mike Aspinall’s men after five players were sin-binned throughout the 80 minutes.
Chris Wilson and Harry Parrish were ‘Gate’s try-scorers with Callum Irvine converting.
Knaresborough Town produced a strong rear-guard display NCEL Division One Shaw Lane Aquaforce, but the league leaders eventually secured a deserved 1-0 win.
Brian Davey’s 16th placed side travel to Pontefract Collieries on Tuesday.